2,6-Dimethylmorpholine, cis- → HCID 59278679, compound

HRID 1942886Notes

Reaction equation

HRID 1942886 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]3)=[C:13]([O:23][CH3:24])[CH:12]=2)[N:3]=1.[CH3:25][C@H:26]1[O:31][C@@H:30]([CH3:32])[CH2:29][NH:28][CH2:27]1>>[CH3:32][C@@H:30]1[O:31][C@H:26]([CH3:25])[CH2:27][N:28]([C:2]2[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]4)=[C:13]([O:23][CH3:24])[CH:12]=3)[N:3]=2)[CH2:29]1

Participants

3

Reactant 2

HCID 6415002,6-Dimethylmorpholine, cis-HCID 86640783(4-Chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Product 1

HCID 59278679HCID 59278679, compound

Procedure

The title compound was prepared from (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and cis-2,6-dimethylmorpholine in analogy to example 1c. It was purified by column chromatography on Si—NH2 gel (Isolute) using ethyl acetate as eluent to give the title compound as a yellowish solid in 58% yield.

Workup

  1. customIt was purified by column chromatography on Si—NH2 gel (Isolute)

Sources & evidence

ORD record
ord-507c714316bc409da2e8d650e21678e4
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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