2-Chloro-4-methoxy-6-methyl-1,3,5-triazine → [3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(4-methoxy-6-methyl-[1,3,5]triazin-2-yl)-amine

HRID 1942891Notes

Reaction equation

HRID 1942891 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.Cl[C:17]1[N:22]=[C:21]([O:23][CH3:24])[N:20]=[C:19]([CH3:25])[N:18]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:17]2[N:22]=[C:21]([O:23][CH3:24])[N:20]=[C:19]([CH3:25])[N:18]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1

Participants

3

Reactant 2

HCID 193920792-Chloro-4-methoxy-6-methyl-1,3,5-triazineHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 59278676[3-Methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-(4-methoxy-6-methyl-[1,3,5]triazin-2-yl)-amineYield 32%

Procedure

This compound was prepared from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 2-chloro-4-methoxy-6-methyl-[1,3,5]triazine in analogy to example 1c. It was purified by chromatography on Si—NH2 (Isolute) using ethyl acetate as an eluent to give the title compound as a slightly yellowish solid in 32% yield.

Workup

  1. customIt was purified by chromatography on Si—NH2 (Isolute)

Sources & evidence

ORD record
ord-e9b9cd6e7eed4a7190681f028ff49fa3
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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