(2-Methoxyethyl)(methyl)amine → HCID 59278678, compound

HRID 1942893Notes

Reaction equation

HRID 1942893 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]3)=[C:13]([O:23][CH3:24])[CH:12]=2)[N:3]=1.[CH3:25][O:26][CH2:27][CH2:28][NH:29][CH3:30]>>[CH3:9][O:8][C:6]1[N:7]=[C:2]([N:29]([CH2:28][CH2:27][O:26][CH3:25])[CH3:30])[N:3]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]3)=[C:13]([O:23][CH3:24])[CH:12]=2)[N:5]=1

Participants

3

Reactant 2

HCID 300977(2-Methoxyethyl)(methyl)amineHCID 86640783(4-Chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

Product 1

HCID 59278678HCID 59278678, compoundYield 51%

Procedure

This compound was prepared from (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine and N-(2-methoxyethyl)methylamine in analogy to example 1c. It was purified by chromatography on Si—NH2 (Isolute) using ethyl acetate as an eluent to give the title compound as a slightly yellowish solid in 51% yield.

Workup

  1. customIt was purified by chromatography on Si—NH2 (Isolute)

Sources & evidence

ORD record
ord-ba7fd8a65e70410b97e8cd889d732025
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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