2-Chloro-3-pyridinol → HCID 59278670, compound

HRID 1942902Notes

Reaction equation

HRID 1942902 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH:21]=[C:20]([CH2:22][OH:23])[N:19]=[CH:18]3)=[C:13]([O:24][CH3:25])[CH:12]=2)[N:3]=1.[Cl:26][C:27]1[C:32]([OH:33])=[CH:31][CH:30]=[CH:29][N:28]=1>>[Cl:26][C:27]1[C:32]([O:33][C:2]2[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH:21]=[C:20]([CH2:22][OH:23])[N:19]=[CH:18]4)=[C:13]([O:24][CH3:25])[CH:12]=3)[N:3]=2)=[CH:31][CH:30]=[CH:29][N:28]=1

Participants

3

Reactant 2

HCID 811362-Chloro-3-pyridinolHCID 86640786HCID 86640786, compound

Product 1

HCID 59278670HCID 59278670, compoundYield 43%

Procedure

This compound was prepared in analogy to example 3 from {1-[4-(4-chloro-6-methoxy-[1,3,5]triazin-2-ylamino)-2-methoxy-phenyl]-1H-imidazol-4-yl}-methanol and 2-chloro-3-hydroxypyridine. The title compound was isolated as a slightly brownish solid in 43% yield.

Sources & evidence

ORD record
ord-2dbd1afdd1fe4753af42ee555df44c0c
Source dataset
uspto-grants-2013_03
Patent number
US08389717B2

Reaction notes

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