Hydrochloric Acid → Sitagliptin monohydrochloride

Participants

Reaction Conditions

Reaction Steps

Sitagliptin base (150 mg) was suspended in 2-propanol (2.5 mL). Hydrochloric acid (36 mg of 37% aqueous solution) was added and the mixture was stirred for one hour at ambient temperature and 2 hours at 40° C. The mixture was allowed to cool to ambient temperature and stirred for 24 hours before evaporation of the solvent.

Provenance & Evidence