HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → N-(6,7-Methylenedioxyquinolin-4-yl)-N-[2-(N,N-dimethylamino)--methylethyl)-2-iodo-4,5-dimethoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | 2-Iodo-5,6-dimethoxybenzoic acid | HCID 10662557 | — |
| Reactant | N'-(6,7-Methylenedioxyquinolin-4-yl)-N,N-dimethylpropane-1,2-diamine | HCID 22139515 | — |
| Product | N-(6,7-Methylenedioxyquinolin-4-yl)-N-[2-(N,N-dimethylamino)--methylethyl)-2-iodo-4,5-dimethoxybenzamide | HCID 22139524 | 60.4% |
Reaction Steps
Prepared from N′-(6,7-Methylenedioxyquinolin-4-yl)-N,N-dimethylpropane-1,2-diamine (273 mg, 1.0 mol) in 60.4% yield with a reaction time of 12 h, from the acid chloride prepared using 4.8 mmol of oxalyl chloride and 1.2 mmol of 2-iodo-5,6-dimethoxybenzoic acid. Compound 7b had: mp 82-84° C.; IR (KBr) 1648, 3415; HRMS calcd for C24H26IN3O5H 564.0917; found 564.0997
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389721B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-025d6b3ce25740e69e3641f76594773b |
| Source note | uspto-grants-2013_03 |