Zincchloride → HCID 87229536, compound

HRID 1942928Notes

Reaction equation

HRID 1942928 reaction equation
[CH3:1][N:2]=[C:3]([NH2:9])[NH:4][C:5](=[N:7][CH3:8])[NH2:6].CC(C)([O-])C.[K+].[Cl-].[Zn+2:17].[Cl-]>O.C(O)(C)(C)C.C(OCC)C>[Zn:17].[CH3:1][N:2]=[C:3]([NH2:9])[NH:4][C:5](=[N:7][CH3:8])[NH2:6]

Participants

7

Reactant 3

HCID 3007855ZincchlorideHCID 10197701HCID 10197701, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 87229536HCID 87229536, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 3283Diethyl EtherSolventHCID 6386tert-ButanolSolvent

Procedure

Dimethylbiguanide (33 mg) was dissolved in 1 mL of water, after which 0.44 mL of 1 M potassium t-butoxide in t-butanol was added and the solution stirred for 10 minutes. Zinc chloride in diethyl ether (0.22 mL of 1M solution) was added and the solution stirred for 5 hours. The resultant precipitant was separated from the liquid by centrifuging at 8,000 rpm for 6 minutes and the supernatant was decanted. The pellet was washed by adding 1 mL of water, vortex mixed, centrifuged and the supernatant decanted. After an overnight drying under high vacuum the yield was 20 mg of a free flowing white powder which contained no organic material by 1H NMR. The isolated product was zinc salts in various hydrated forms.

Workup

  1. stirringthe solution stirred for 5 hours
  2. customThe resultant precipitant was separated from the liquid by centrifuging at 8,000 rpm for 6 minutes
  3. customthe supernatant was decanted
  4. washThe pellet was washed
  5. additionby adding 1 mL of water, vortex
  6. additionmixed
  7. customAfter an overnight drying under high vacuum the yield was 20 mg of

Sources & evidence

ORD record
ord-815041d4558742b5a0968ec21863b77b
Source dataset
uspto-grants-2013_03
Patent number
US08389726B2

Reaction notes

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