HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(5-Chloro-2-methoxyphenyl)thiourea → 2-(5-Chloro-2-methoxyphenylamino)-4,5,6,7-tetrahydrocyclohepta[d]thiazol-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(5-Chloro-2-methoxyphenyl)thiourea | HCID 2732660 | — |
| Reactant | 2-amino-4H,5H,6H,7H,8H-cyclohepta[d][1,3]thiazol-8-one | HCID 25130828 | — |
| Product | 2-(5-Chloro-2-methoxyphenylamino)-4,5,6,7-tetrahydrocyclohepta[d]thiazol-8-one | HCID 25131146 | 26% |
Reaction Steps
Following the procedure described for 26z by condensing 5-chloro-2-methoxyphenylthiourea gave 30z (light brown solid; 26% for two steps). 1H NMR (600 MHz, DMSO-d6): δ 7.81 (d, J=2.4 Hz, 1H), 7.75 (dd, J=9 Hz, 2.4 Hz, 1H), 7.42 (d, J=9 Hz, 1H), 3.83 (s, 3H), 2.84-2.75 (m, 2H), 2.58-2.52 (m, 1H), 2.33-2.28 (m, 1H), 1.90-1.74 (m, 4H). 13C NMR (150 MHz, DMSO-d6): δ 194.4, 169.8, 154.5, 148.9, 134.1, 130.2, 125.7, 122.6, 121.7, 116.3, 57.6, 42.9, 30.5, 24.4, 21.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389736B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-54cfb37981694aa482e7a94cf71dac0c |
| Source note | uspto-grants-2013_03 |