HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → Teriflunomide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | 2-Butenoic acid, 2-cyano-3-hydroxy-, ethyl ester | HCID 76179710 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | Teriflunomide | HCID 54684141 | 71.2% |
Reaction Steps
Ethyl 2-cyano-3-hydroxybut-2-enoate (III) (50 g) and 4-(trifluoromethyl) aniline (51.9 g) in xylene (1000 ml) was refluxed for 48 hours. The reaction mixture was allowed to cool at room temperature. Separated solid was filtered and washed with xylene (2×100 ml). Solid was dried under vacuum at 70° C. to yield (62 g) of Teriflunomide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389757B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-5e20d06d58c240d8b3aac1a708933418 |
| Source note | uspto-grants-2013_03 |