反应详情

A solution of N-(3-bromo-6-chloro-2-pyridinyl)-2,2-dimethyl-N-2-propen-1-ylpropanamide (12.388 g, 37.370 mmol) in methanol (100 ml) at rt under argon was treated with sodium methoxide solution (25% w/v in methanol, 17.76 g, 82.212 mmol) and then heated at reflux for 42 h. The reaction was then cooled, treated with water (500 ml), and extracted with diethyl ether (3×200 ml). The organic extracts were dried (MgSO4), and evaporated to give the product (10.918 g, 89%).

1. temperatureheated
2. temperatureat reflux for 42 h
3. temperatureThe reaction was then cooled
4. extractionextracted with diethyl ether (3×200 ml)
5. dry with materialThe organic extracts were dried (MgSO4)
6. customevaporated