Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(N-Boc-amino)piperidine → 1,1-Dimethylethyl (1-{2-hydroxy-3-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]propyl}-4-piperidinyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 반응물 | 7-(Methyloxy)-1-(2-oxiranylmethyl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one | HCID 86642091 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1,1-Dimethylethyl (1-{2-hydroxy-3-[7-(methyloxy)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl]propyl}-4-piperidinyl)carbamate | HCID 69046556 | 38% |
반응 단계
A solution of 7-(methyloxy)-1-(2-oxiranylmethyl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one (428 mg, 1.829 mmol) and 1,1-dimethylethyl 4-piperidinylcarbamate (366 mg, 1.829 mmol) in DMF (2 ml) under argon was heated at 120° C. for 1 h. The mixture was then evaporated and chromatographed (0-10% methanol/DCM) to give the product as a yellow oil (301 mg, 38%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08389524B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-4bb6652f8eb747718ddb08b5f1599f4b |
| 출처 메모 | uspto-grants-2013_03 |