Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methyl-1-pentyne → 2,2,2-Trifluoro-n-(3-hydroxy-3-(3-(4-methylpent-1-ynyl)phenyl)propyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methyl-1-pentyne | HCID 138948 | — |
| 반응물 | N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide | HCID 57608426 | — |
| 생성물 | 2,2,2-Trifluoro-n-(3-hydroxy-3-(3-(4-methylpent-1-ynyl)phenyl)propyl)acetamide | HCID 87081518 | — |
반응 단계
Sonogashira reaction of 25 with 4-methyl-pent-1-yne yielded 2,2,2-trifluoro-N-(3-hydroxy-3-(3-(4-methylpent-1-ynyl)phenyl)propyl)acetamide as dark brown oil. Yield (0.94 g, 94%): 1H NMR (400 MHz, CDCl3) δ 7.38 (s, 1H), 7.25-7.35 (m, 3H), 4.86 (m, 1H), 3.67-3.72 (m, 1H), 3.38-3.44 (m, 1H), 2.30 (d, J=6.4 Hz, 2H), 2.28 (bs, 1H), 1.87-1.99 (m, 3H), 1.05 (d, J=6.8 Hz, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08389771B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-d71069645a044874af3d32499c0695e8 |
| 출처 메모 | uspto-grants-2013_03 |