1-Methylpiperazine → HCID 178480661, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-((trans-4-aminocyclohexylamino)-8-(6-bromopyridin-2-ylamino)-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide 17B (35.0 mg, 0.065 mmol) and 1-methylpiperazine (32.4 mg, 0.324 mmol) in NMP (0.4 mL) was heated to 120° C. overnight. The reaction mixture was cooled to room temperature and purified by preparative HPLC. The desired fraction was concentrated and lyophilized to give 17C (23.9 mg, 40%) as light yellow solid. [M+H]=560. HPLC Peak Rt=2.313 minutes. (Chromolith column 4.6×50 mm eluting with 10-90% aqueous methanol over 4 minutes containing 0.1% TFA, 4 mL/min, monitoring at 220 nm.)

Provenance & Evidence