HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamine → 8-(1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-3-ylamino)-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamine | HCID 59344947 | — |
| Reactant | 6,8-Dichloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide | HCID 59624549 | — |
| Reactant | 6-chloro-N-(3-fluoropyridin-4-yl)-8-(1-isopropyl-1H-pyrazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide | HCID 86649269 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-(1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-3-ylamino)-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide | HCID 86649270 | — |
Reaction Steps
Compound 50A was prepared from 6,8-dichloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide and 1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-3-amine in a similar way as 48A. HPLC Rt=3.891 min (Chromolith SpeedROD 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA, 4 min gradient, monitored at 220 nm), [M+H]=531.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389527B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-67955de8985e45a7a74c624a7280f862 |
| Source note | uspto-grants-2013_03 |