5-Bromothiophene-2-carbaldehyde → HCID 58160688, compound

HRID 1943518Notes

Reaction equation

HRID 1943518 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13](B(O)O)=[C:12]([F:19])[CH:11]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].Br[C:21]1[S:25][C:24]([CH:26]=[O:27])=[CH:23][CH:22]=1>>[F:19][C:12]1[CH:11]=[C:10]([C:7]2[CH:8]=[CH:9][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=2)[CH:15]=[CH:14][C:13]=1[C:21]1[S:25][C:24]([CH:26]=[O:27])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 784285-Bromothiophene-2-carbaldehydeHCID 53402576(3-Fluoro-4'-propyl[1,1'-biphenyl]-4-yl)boronic acid

Product 1

HCID 58160688HCID 58160688, compound

Procedure

5-(3-Fluoro-4′-propylbiphenyl-4-yl)thiophene-2-carbaldehyde is prepared analogously to Example 3 by Suzuki coupling of 4′-propyl-3-fluoro-4-biphenylboronic acid to 5-bromothiophene-2-carbaldehyde.

Sources & evidence

ORD record
ord-9f33c8f6555049909b7eb0bbac652398
Source dataset
uspto-grants-2013_03
Patent number
US08394293B2

Reaction notes

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