Sodium Carbonate → 845273-93-0

HRID 1943531Notes

Reaction equation

HRID 1943531 reaction equation
[C:1](=[O:4])([O-:3])[O-:2].[Na+].[Na+].[CH2:7]=[CH:8][CH2:9][NH2:10].[CH2:11]1[O:13][CH:12]1[CH2:14][Cl:15].Cl>O>[CH2:7]=[CH:8][CH2:9][NH3+:10].[CH2:11]1[O:13][CH:12]1[CH2:14][Cl:15].[C:1]([O-:4])([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 159247152751-57-0

Product 1

HCID 49800084845273-93-0Yield 63.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
32.5 °C

Procedure

A 5 L reactor, equipped with a mechanical stirrer, temperature probe, dropping funnel and a condenser topped with a nitrogen inlet, was charged with water (4 L), sodium carbonate (250 g), and the solution was brought at 35° C. Sevelamer hydrochloride (400 g) are added portion wise for 1 h, in portions of 20 g each, while stirring, maintaining the temperature from 30 to 35° C. The solid is then filtered and suspended in water (3 L), at 30-35° C. The mixture is allowed to stir for 20 minutes. The solid was filtered again and rinsed with water until disappearance of chloride ions. The product is dried under reduced pressure at 70° C. to afford Sevelamer carbonate (290 g), with a phosphate binding capacity of 17.2-17.6 mEq/g.

Workup

  1. customA 5 L reactor, equipped with a mechanical stirrer
  2. customtopped with a nitrogen inlet
  3. customwas brought at 35° C
  4. filtrationThe solid is then filtered
  5. customsuspended in water (3 L), at 30-35° C
  6. stirringto stir for 20 minutes
  7. filtrationThe solid was filtered again
  8. washrinsed with water until disappearance of chloride ions
  9. customThe product is dried under reduced pressure at 70° C.

Sources & evidence

ORD record
ord-3fcc64fbcf634f199265b60279a47a19
Source dataset
uspto-grants-2013_03
Patent number
US08394416B2

Reaction notes

Loading…