Dimethyl Sulfoxide → HCID 67534545, compound

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Reaction Steps

Purified dichloro methane anhydride 100 ml is cooled using dry ice and acetone. When the cooling is completed, oxalyl chloride 42.5 ml (0.05 mol) and dimethyl sulfur oxide 5.76 ml (0.08 mol) are added. Thereafter, they are stirred for 10 minutes. Then, (10-oxo-10H-9-oxa-10-phosphaphenanthrene-10-yl)-methanol (compound F) 10 g (0.04 mol) is added thereto. Thereafter, they are stirred for 1 hour. Then, triethylamine 22 ml is slowly added thereto. Thereafter, they are stirred at a normal temperature for 12 hours. When the reaction is completed, distilled water 100 ml is added thereto. Thereafter, solution is extracted using dichloro methane. The extracted solution is processed using 1N-hydrochloric acid water, saturated sodium bicarbonate solution, saturated brine water, or the like, and is dried using magnesium sulfate anhydride. The dried solution is filtered under reduced pressure and evaporated under reduced pressure to obtain brown solution. The obtained product is used for reaction in immediately subsequent step.

Provenance & Evidence