Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Icariin | HCID 5318997 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Icaritin | HCID 5318980 | — |
| Product | Baohuoside-1 | HCID 5745470 | — |
| Product | 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-3-((2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxychromen-4-one | HCID 44587252 | — |
Reaction Steps
20 g of the extract prepared in Example 1 was taken in dry pyridine (500 ml) and sodium methoxide (powder, 10 g) was added thereto. The solution was heated to reflux in a water bath at 80° C. for 8 hours to hydrolyze sugars bonded to icariin. The reaction was concentrated under pressure to remove the solvent. The residue was added to ethanol (200 ml), stirred (3 times) and subjected to filtration to remove precipitated salts. The filtrate was concentrated under pressure to obtain a crude product, which was then separated by silica gel column chromatography (chloroform:methanol=8:1 to 4:1) to give 0.6 g of icaritin, 0.7 g of icariside 1 and 0.8 g of icariside II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08394775B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-575a8382b4a746aab3ea7feeb32a2ece |
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| Source note | uspto-grants-2013_03 |
|---|
