HCID 178418361, compound → 3-Amino-6-methylpyridin-2-ol

HRID 1943636Notes

Reaction equation

HRID 1943636 reaction equation
[OH:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-])=O.[H][H]>CO.ClCCl.[Pd]>[NH2:9][C:3]1[C:2]([OH:1])=[N:7][C:6]([CH3:8])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178426723HCID 178426723, compound

Product 1

HCID 1784266163-Amino-6-methylpyridin-2-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21226129Dichloromethane methanolSolvent

Procedure

6-hydroxy-5-nitro-2-picoline (500 mg, 3.247 mmol) was dissolved in methanol:dichloromethane (5:1, 60 ml) and 10% palladium on active carbon was added thereto slowly, and then stirred for 2 hours with adding hydrogen gas at room temperature. The reaction mixture was filtered by using celite and evaporated under reduced pressure to quantitatively obtain white solid (400 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated under reduced pressure to quantitatively obtain white solid (400 mg)

Sources & evidence

ORD record
ord-cfedb30f47e6402ca63b7fc6abb6231b
Source dataset
uspto-grants-2013_03
Patent number
US08394792B2

Reaction notes

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