HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 3,4-Dihydro-2,2-dimethyl-2H-pyrido[4,3-b]-1,4-oxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | HCID 10678883 | HCID 10678883 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Product | 3,4-Dihydro-2,2-dimethyl-2H-pyrido[4,3-b]-1,4-oxazine | HCID 15857210 | 100% |
Reaction Steps
By the same method as in the step c) of Example 2, 2,2-dimethyl-4H-pyrido[4,3-b][1,4]oxazin-3-one (120 mg, 0.67 mmol) was reacted with 1.0M Lithium aluminum hydride dissolved in tetrahydrofuran (1.4 ml, 1.4 mmol) to obtain 2,2-dimethyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (110 mg, quantitative yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394792B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-856e99661f2f438e95b0e4d7b57d866b |
| Source note | uspto-grants-2013_03 |