Potassium Carbonate → HCID 66936594, compound

Participants

Reaction Steps

To a 10 ml flask, 7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2-one (400 mg, 1.746 mmol), cyclopropyl boronic acid (165 mg, 1.921 mmol), palladium acetate (39.1 mg, 0.174 mmol), triphenylphosphine (91.5 mg, 0.349 mmol) and potassium carbonate (482.6 mg, 3.492 mmol) were dissolved in a solvent of acetonitrile/water (6/1, 4.2 ml/0.9 ml). The reaction mixture was stirred for 60 minutes at 100□ using microwave (100 W) apparatus. After cooling to room temperature, the reaction mixture was extracted with ethyl acetate and the organic layer was washed with saturated saline solution. The combined organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica eluting with a solvent of dichloromethane and ethyl acetate. The fractions containing the product were collected and evaporated to obtain a mixture (40 mg, 0.8%) containing triphenyl phosphoxide.

Provenance & Evidence