Boron tribromide → HCID 44608380, compound

HRID 1943683Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[CH:19][N:20]=[CH:21][C:13]2=3)=[O:11])[CH:5]=[CH:6][C:7]=1[O:8]C.B(Br)(Br)Br>>[Br:1][C:2]1[CH:3]=[C:4]([C:10]([N:12]2[CH2:17][CH2:16][O:15][C:14]3[CH:18]=[CH:19][N:20]=[CH:21][C:13]2=3)=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 66936511(3-Bromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone

Product 1

HCID 44608380HCID 44608380, compoundYield 89.9%

Procedure

By the same method as in Example 3, (3-bromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (296 mg, 0.85 mmol) and 1M solution of boron tribromide (4.25 ml, 4.25 mmol) were reacted to obtain the target compound 38, i.e., (3-bromo-4-hydroxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (256 mg, 89%).

Sources & evidence

ORD record: ord-4735945a38f845268ced0e057418dce8
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394792B2

Reaction notes

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