Lawesson's reagent → HCID 86650560, compound

Participants

Reaction Steps

In a 25 ml flask, (3,5-dibromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (100 mg, 0.23 mmol) was suspended in toluene, and Lawesson's reagent (113 mg, 1.2 equivalents) was added thereto and then stirred at 120□ for 2 hours. Toluene was evaporated under reduced pressure and the residue was purified on amine silica by using a solvent of dichloromethane:methanol=50:1 to obtain (3,5-dibromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanethione (100 mg, 98%).

Provenance & Evidence