Piperazine → HCID 135895368, compound

Participants

Reaction Steps

In a 25 ml flask, (3,5-dibromo-4-methoxy-phenyl)-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanethione (100 mg, 0.22 mmol) was dissolved in N,N-dimethyl formamide, and piperazine (28.4 mg, 1.5 equivalents) and lithium bromide (76.4 mg, 4 equivalents) were added thereto and then stirred at 1000 for 15 hours. N,N-dimethyl formamide was removed under reduced pressure and water was added the residue. The mixture in suspension was adjusted to pH 6 to 7 by using 1N hydrochloric acid and stirred for 30 minutes. The mixture was filtered and the resulting solid was stirred in methanol solvent and then filtered to give the target compound 51 as yellow solid (100 mg, quantitative yield).

Provenance & Evidence