Potassium Carbonate → HCID 66936637, compound

Participants

Reaction Steps

To 2.0 ml of acetonitrile/0.5 ml of distilled water, 7-bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine (80 mg, 0.372 mmol), 3-furan boronic acid (45.7 mg, 0.409 mmol), palladium acetate (8.3 mg, 0.0372 mmol), triphenylphosphine (19.5 mg, 0.0744 mmol) and potassium carbonate (102.8 mg, 0.744 mmol) were added and reacted at 100□ for 10 min using microwave (50 W) apparatus. After completion of the reaction, the mixture was extracted with ethyl acetate, and the combined organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and evaporated under reduced pressure. The residue was purified by preparative TLC eluting a solvent of dichloromethane:methanol=20:1. Silica gels containing the product were eluted with dichloromethane and the solvent was evaporated to obtain 7-furan-3-yl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine in oil form (18 mg, 24%).

Provenance & Evidence