Piperazine → HCID 44609033, compound

Participants

Reaction Steps

By the same method as in the step d) of Example 45, (3,5-dibromo-4-methoxy-phenyl)-[7-(3-trifluoromethyl-phenyl)-2,3-dihydro-pyrido[2,3-b][1,4]oxazin-1-yl]-methanone (165 mg, 0.29 mmol), lithium bromide (100 mg, 1.15 mmol) and piperazine (37.3 mg, 0.43 mmol) were dissolved in N,N-dimethyl formamide (2 ml) and reacted at 100□ to obtain the target compound 63, i.e., (3,5-dibromo-4-hydroxy-phenyl)-[7-(3-trifluoromethyl-phenyl)-2,3-dihydro-pyrido[2,3-b][1,4]oxazin-1-yl]-methanone, as white solid (90 mg, 56%).

Provenance & Evidence