Piperazine → 4-[1-(3,5-dibromo-4-hydroxy-benzoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl]-benzonitrile

Participants

Reaction Steps

By the same method as in the step d) of Example 45, 4-[1-(3,5-dibromo-4-methoxy-benzoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl]-benzonitrile (116 mg, 0.22 mmol), lithium bromide (76 mg, 0.88 mmol) and piperazine (29 mg, 0.33 mmol) were dissolved in N,N-dimethyl formamide (3 ml) and reacted at 1000 to obtain the target compound 65, i.e., 4-[1-(3,5-dibromo-4-hydroxy-benzoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl]-benzonitrile, as white solid (49 mg, 43%).

Provenance & Evidence