Piperazine → HCID 44609036, compound

Participants

Reaction Steps

By the same method as in the step d) of Example 45, (3,5-dibromo-4-methoxy-phenyl)-[7-(4-trifluoromethoxy-phenyl)-2,3-dihydro-pyrido[2,3-b][1,4]oxazin-1-yl]-methanone (110 mg, 0.19 mmol), lithium bromide (65 mg, 0.75 mmol) and piperazine (25 mg, 0.29 mmol) were dissolved in N,N-dimethyl formamide (3 ml) and reacted at 100□ to obtain the target compound 66, i.e., (3,5-dibromo-4-hydroxy-phenyl)-[7-(4-trifluoromethoxy-phenyl)-2,3-dihydro-pyrido[2,3-b][1,4]oxazin-1-yl]-methanone, as white solid (54 mg, 48%).

Provenance & Evidence