Potassium Carbonate → HCID 178508012, compound

Participants

Reaction Steps

K2CO3 (0.233 g, 1.68 mmol) was added to a solution of 3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-amine (0.206 g, 0.56 mmol) in MeOH/H2O (3:1, 8 mL), and the reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated. The resulting residue was taken up in water (10 mL), and the pH was adjusted to about 7 with acetic acid. The aqueous layer was extracted with ethyl acetate (3×50 mL) The combined organic layers were dried, filtered and concentrated. The crude product was purified by column chromatography, eluting with hexanes/ethyl acetate (1:4) to give 3-bromo-1H-pyrazolo[3,4-b]pyridin-5-amine (0.036 g, 30%) as a solid.

Provenance & Evidence