Hydrochloric Acid → HCID 178461058, compound

Participants

Reaction Steps

tert-Butyl 4-(5-(2,6-difluoro-3-(propylsulfonamido)benzamido)-1H-pyrazolo[3,4-b]pyridin-3-yl)piperidine-1-carboxylate (7 mg, 0.01 mmol) was treated with a 0.5M solution of HCl in dioxane (0.5 mL, 2 mmol) at room temperature for 1 hour. The volatiles were removed in vacuo to afford 2,6-difluoro-N-(3-(piperidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide hydrochloride as a solid (5 mg, 83%). 1H NMR (400 MHz, CD3OD) δ 8.87-8.90 (m, 1H), 8.62-8.58 (m, 1H), 7.70-7.64 (m, 1H), 7.18-7.13 (m, 1H), 3.76-3.52 (m, 3H), 3.33-3.22 (m, 2H), 3.15-3.11 (m, 2H), 2.38-2.30 (m, 2H), 2.25-2.13 (m, 2H), 1.93-1.83 (m, 2H), 1.06 (t, J=7.4 Hz, 3H). m/z (APCI-pos) M+1=479.2.

Provenance & Evidence