反应详情

温度

90 °C

A suspension of 1H-pyrazol-5-amine (0.804 g, 9.48 mmol) and sodium nitromalonaldehyde monohydrate (1.56 g, 9.96 mmol) in acetic acid (12 mL) was heated to 90° C. overnight. The reaction mixture was cooled to room temperature and poured into water (50 mL). The resulting solids were collected by filtration. The solids were washed with water (3×20 mL) and dried in vacuo to give 5-nitro-1H-pyrazolo[3,4-b]pyridine (1.40 g, 84%) as a solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationThe resulting solids were collected by filtration
3. washThe solids were washed with water (3×20 mL)
4. customdried in vacuo