反应详情

5-Bromo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-ol (0.200 g, 0.599 mmol) was dissolved in DMF. Sodium hydride (0.0287 g, 0.718 mmol) was added and stirred for 10 minutes. Methyl iodide (0.0448 mL, 0.718 mmol) was added, and the reaction mixture was stirred overnight. The solution was partitioned between water and EtOAc. The organic layer was washed with water (3×), brine, dried over Na2SO4 and concentrated to an oil, which was purified by column chromatography (2:1 hexanes/EtOAc) to give 5-bromo-3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine (0.11 g, 52.3%) as an oil.

1. stirringthe reaction mixture was stirred overnight
2. customThe solution was partitioned between water and EtOAc
3. washThe organic layer was washed with water (3×), brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated to an oil, which
6. customwas purified by column chromatography (2:1 hexanes/EtOAc)