Sodium nitromalonaldehyde hydrate → HCID 178526792, compound

Participants

Reaction Conditions

Reaction Steps

A 50 mL reaction vessel was charged with 3-(pyridin-2-yl)-1H-pyrazol-5-amine (1.5 g, 9.4 mmol), sodium nitromalonaldehyde monohydrate (1.54 g, 9.8 mmol) and water (9 mL). The flask was heated to 100° C. overnight, and the cooled reaction mixture was extracted with ethyl acetate (3×25 mL). The combined organic layers were dried (MgSO4), to provide crude 3-(pyridin-2-yl)-5-nitro-1H-pyrazolo[3,4-b]pyridine (2.0 g, 88% yield) as a solid.

Provenance & Evidence