Sodium nitromalonaldehyde hydrate → HCID 178526793, compound

Participants

Reaction Conditions

Reaction Steps

A round-bottom flask was charged with 3-(2,2,2-trifluoroethyl)-1H-pyrazol-5-amine (0.145 g, 0.878 mmol, WO 2008/005956), sodium nitromalonaldehyde monohydrate (0.150 g, 0.966 mmol) and water (3.5 mL). The reaction mixture was heated at 85° C. for 16 hours. The reaction mixture was poured into water and subsequently extracted with ethyl acetate (2×). The combined organic layers were dried with sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by flash chromatography to afford 5-nitro-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-b]pyridine (0.078 g, 36%).

Provenance & Evidence