HCID 178520053, compound → HCID 178508017, compound

Participants

Reaction Steps

SnCl2 dihydrate (0.24 g, 1.1 mmol) was added to cyclopropyl(5-nitro-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone (0.050 g, 0.22 mmol) in EtOAc (1 mL). The reaction mixture was heated to reflux for 6 hours. The mixture was then cooled, diluted with EtOAc (5 mL), aqueous bicarbonate (5 mL) and filtered through celite. The organic layers were extracted with EtOAc (3×5 mL), dried over sodium sulfate, and concentrated to provide (5-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)(cyclopropyl)methanone (0.035 g, 0.17 mmol, 80% yield).

Provenance & Evidence