Potassium Carbonate → HCID 86652504, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(2-fluoroethoxy)-5-nitro-1-tosyl-1H-pyrazolo[3,4-b]pyridine (0.273 g, 0.718 mmol) and aqueous K2CO3 (1.8 mL, 2M) in MeOH (14 mL) was heated at 55° C. for 1 hour. After cooling to room temperature, the mixture was diluted with 10% aqueous citric acid, extracted with EtOAc, washed with saturated aqueous NaHCO3 and brine, dried over MgSO4, and concentrated to give 3-(2-fluoroethoxy)-5-nitro-1H-pyrazolo[3,4-b]pyridine. The material was purified by silica gel flash column chromatography (1% MeOH in CH2Cl2) to afford 3-(2-fluoroethoxy)-5-nitro-1H-pyrazolo[3,4-b]pyridine along with a byproduct. LRMS (ESI pos) m/e 207.0 (M−F).

Provenance & Evidence