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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1943992Generated: October 31, 2026

2-Bromo-1-(thiophen-2-yl)ethan-1-one → HCID 66863365, compound

https://huagongshe.com/reaction/1943992

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-(thiophen-2-yl)ethan-1-oneHCID 2776372—
ReactantN-[6-aminopyrid-3-yl]-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamideHCID 66863527—
SolventAcetonitrileHCID 6342—
ProductHCID 66863365HCID 66863365100%

Reaction Steps

Compound 6 was prepared according to a process similar to that described in step 4.3, by reacting 0.1 g (0.26 mmol) of N-[6-aminopyrid-3-yl]-5-fluoro-1-[(3-fluorophenyl)-methyl]-1H-indole-2-carboxamide, prepared according to the protocol described in step 4.2, with 0.11 g (0.53 mmol) of 2-bromo-1-(thien-2-yl)ethanone in 4 mL of acetonitrile. 0.126 g of the expected product is thus obtained in the form of a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08394820B2
Source datasetuspto-grants-2013_03
ORD IDord-8c5f4c849e594af5822b2e30bb492495
Source noteuspto-grants-2013_03