Chloroacetone → N-(2-Methylimidazo[1,2-a]pyrid-7-yl)-5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide

Participants

Reaction Steps

Compound 19 was prepared according to a process similar to that described in step 10.2, by reacting 0.12 g (0.32 mmol) of N-[2-aminopyrid-4-yl]-5-fluoro-1-[(3-fluoro-phenyl)methyl]-1H-indole-2-carboxamide, prepared according to the protocol described in step 10.1, with 0.059 g (0.63 mmol) of 1-chloropropan-2-one in 4 mL of acetonitrile. 50 mg of the expected product are thus obtained.

Provenance & Evidence