HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1944026Generated: November 2, 2026
Acetic Acid → Diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate
https://huagongshe.com/reaction/1944026
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Bromo-6-fluoroaniline | HCID 2782940 | — |
| Reactant | Diethyl 4,4-diethoxyheptanedioate | HCID 59487222 | — |
| Product | Diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate | HCID 59487249 | — |
Reaction Steps
To the ketal of Step 1 (8.46 kg, 24.31 mol), were charged 2-bromo-6-fluoroaniline (2.509 L, 22.10 mol) and acetic acid (0.253 L, 4.42 mol) under nitrogen. The mixture was heated to 145° C. and ethanol was removed by distillation. The product was used in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08394819B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-880fbc829cb54b28ad550f2ac7dd300d |
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| Source note | uspto-grants-2013_03 |
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