Propyl (7-azido-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate → {7-[4-(4-Methanesulfonylamino-butyl)-[1,2,3]triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}-acetic acid

HRID 1944030Notes

Reaction equation

HRID 1944030 reaction equation
[N:1]([CH:4]1[CH2:23][N:8]2[C:9]3[C:14]([C:15]([CH2:16][C:17]([O:19]CCC)=[O:18])=[C:7]2[CH2:6][CH2:5]1)=[CH:13][CH:12]=[CH:11][CH:10]=3)=[N+:2]=[N-:3].[CH2:24]([NH:30][S:31]([CH3:34])(=[O:33])=[O:32])[CH2:25][CH2:26][CH2:27][C:28]#[CH:29]>>[CH3:34][S:31]([NH:30][CH2:24][CH2:25][CH2:26][CH2:27][C:28]1[N:3]=[N:2][N:1]([CH:4]2[CH2:23][N:8]3[C:9]4[C:14]([C:15]([CH2:16][C:17]([OH:19])=[O:18])=[C:7]3[CH2:6][CH2:5]2)=[CH:13][CH:12]=[CH:11][CH:10]=4)[CH:29]=1)(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 59487226Propyl (7-azido-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetateHCID 77231298N-hex-5-yn-1-ylmethanesulfonamide

Product 1

HCID 46891993{7-[4-(4-Methanesulfonylamino-butyl)-[1,2,3]triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}-acetic acid

Procedure

The title compound was prepared using procedures described in EXAMPLE 1 from propyl (7-azido-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate and N-hex-5-yn-1-ylmethanesulfonamide. MS (+ESI) m/z: 446.2.

Sources & evidence

ORD record
ord-5eef36c1049e4a87a7df8f2fb10b0f54
Source dataset
uspto-grants-2013_03
Patent number
US08394819B2

Reaction notes

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