HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzyl chloride → {(R)-7-[5-(4-Fluoro-benzyl)-[1,2,3]triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzyl chloride | HCID 9602 | — |
| Reactant | Azide | HCID 33558 | — |
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 1-Fluoro-4-prop-2-ynyl-benzene | HCID 10558668 | — |
| Reactant | {7-[5-(1-Phenyl-cyclopentyl)-[1,2,3]triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}-acetic acid | HCID 46893926 | — |
| Product | {(R)-7-[5-(4-Fluoro-benzyl)-[1,2,3]triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}-acetic acid | HCID 46892777 | — |
Reaction Steps
The title compound was prepared using enantiomerically pure propyl (7-azido-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate from EXAMPLE 6 and 1-fluoro-4-prop-2-yn-1-ylbenzene prepared from 4-fluorobenzyl chloride and ethynyltrimethylsilane described in EXAMPLE 8. EXAMPLE 28.1 and 28.2 were prepared from the chiral azide with the retention time of 10.3 and 11.5 min respectively from EXAMPLE 6. MS (+ESI) m/z: 405.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394819B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-ddb93b0176ed4aeb8b3f6a33c94267c6 |
| Source note | uspto-grants-2013_03 |