Lithium Hydroxide → HCID 59487230, compound

Participants

Reaction Steps

Each of the chiral resolved ethyl {4-fluoro-7-[5-(4-fluorobenzyl)-4-methyl-1H-1,2,3-triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetate was hydrolyzed to the final acid product by dissolving in 1:1:1 THF/MeOH/water (0.06 M), treating with LiOH (3.6 eq.) and stirring overnight. The reaction mixture was diluted with EtOAc, extracted with 2 N HCl, water, dried (Na2SO4), and concentrated to provide {4-fluoro-7-[5-(4-fluorobenzyl)-4-methyl-1H-1,2,3-triazol-1-yl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetic acid Examples 36.1 and 36.2: MS (EI) calc'd for C24H23F2N4O2 [M+1]+437.2. found 437.1.

Provenance & Evidence