2-Aminophenol → 2-bromo-N-(2-hydroxyphenyl)-2-methylpropionamide

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-aminophenol (10 g, 9.2 mmol) in DCM (92 ml) at 0° C. was added 2-bromoisobutyryl bromide (11.4 ml, 9.17 mmol) followed by triethyl amine (12.7 ml, 9.2 mmol) and stirred the reaction mixture at 0° C. for 4 h. Reaction mixture was diluted with DCM 100 ml and then washed with water 100 ml dried over sodium sulfate, concentrated on rotavap to give 2-Bromo-N-(2-hydroxy-phenyl)-2-meth yl-propionamide (21.8 g) brown solid which was used for next reaction without purification

Provenance & Evidence