Hydrochloric Acid → HCID 52914480, compound

Participants

Reaction Steps

To a solution of (5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]octane (70 mg, 0.10 mmole) in methanol (3 mL), 10% Pd/C (45 mg) and 2 drops of con. HCl added and stirred under hydrogen atmosphere at room temperature for 18 hours. The reaction mixture was filtered through celite bed, washed with methanol (20 mL). Crude product was purified by preparative HPLC to furnish 15 mg of the title compound.

Provenance & Evidence