Boron tribromide → HCID 52914599, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester (300 mg, 0.56 mmole) in dry dichloromethane (5 mL), BBr3 (0.54 mL, 5.6 mmole) was added at −78° C. and stirred at −15° C. for 1 hour. The reaction mixture was diluted with diethyl ether (5.0 mL), stirred for 30 min. and further diluted with water (15 mL) and extracted with DCM (2×50 mL) to furnish 280 mg of Acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester.

Provenance & Evidence