Hydrochloric Acid → HCID 52914725, compound

Participants

Reaction Steps

To a solution of {(3S,4R,5S,6S)-3,4,5-Tris-benzyloxy-6-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-2-hydroxymethyl-tetrahydro-pyran-2-yl}-methanol (125 mg, 0.16 mmole) in methanol (3 mL), 10% Pd/C (65 mg) and 2 drops of con. HCl were added and stirred under hydrogen atmosphere at room temperature for 18 hours. The reaction mixture was filtered through cetlie bed, washed with methanol (20 mL). The crude product was purified by preparative HPLC to furnish 25 mg of (3S,4R,5R,6S)-6-[4-Chloro-3-(4-ethoxy-benzyl)-phenyl]-2,2-bis-hydroxymethyl-tetrahydro-pyran-3,4,5-triol.

Provenance & Evidence