Azobisisobutyronitrile → HCID 67074567, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-2,2-bis-iodomethyl-tetrahydro-pyran (100 mg, 0.10 mmole) in toluene (2 mL), tristrimethylsilllylsilane (0.1 mL), AIBN (12 mg) was added and heated at 120° C. for 24 hour in a sealed tube. The reaction mixture was diluted with methanol and evaporated, washed with water (10 mL) and extracted with Ethyl acetate (3×15 mL). The crude product obtained after the removal of solvent to furnish 100 mg of crude (3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-2,2-dimethyl-tetrahydro-pyran.

Provenance & Evidence