Sodium Sulfate → HCID 52913014, compound

Participants

Reaction Steps

To a solution of (5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]octane-1-carboxylic acid ethyl ester (350 mg, 0.46 mmole) in dry tetrahydrofuran (5 mL), lithium aluminium hydride (36 mg, 9.3 mmole) was added at 0° C. and stirred for 4 hours. The excess lithium aluminium hydride was decomposed by adding saturated aqueous sodium sulfate and extracted with Ethyl acetate (3×15 mL). The crude product obtained after the removal of solvent furnished 300 mg mixture of {(5S,6S,7R,8S)-6,7,8-Tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-1-yl}-methanol and {(5S,6S,7R,8S)-6,7,8-Tris-benzyloxy-5-(3-[4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-1-yl}-methanol.

Provenance & Evidence