HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phenol, o-mercapto-(6CI,7CI,8CI) | HCID 70718 | — |
| Reactant | 4-(p-Iodophenyl)butyric acid | HCID 4645427 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid | HCID 68494380 | — |
Reaction Steps
A solution of 4-(4-iodophenyl)butyric acid (0.86M) and dimethylformamide was treated with 2 eq of potassium carbonate, 1.5 eq of 2-hydroxythiophenol and a catalytic amount of cuperic acetate (0.01 eq). The reaction mixture was refluxed for 18 hr, cooled to 25 C, acidified with aqueous acid and extracted with ethyl acetate. The organic phase was concentrated. The residue was purified by flash chromatography using ethyl acetate/hexane as eluant to give 4-(4-(2-hydroxyphenyl)thiophenyl)butyric acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07744910B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e7e01cb1d6b341e290203e4523dd3350 |
| Source note | uspto-grants-2010_06 |