Boron tribromide → HCID 52914599, compound

Participants

Reaction Steps

To a stirred solution of acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester (300 mg, 0.56 mmol) in dry dichloromethane (5 mL) was added BBr3 (0.54 mL, 5.6 mmol) at −78° C. After stirring for 1 h, reaction mixture was diluted with diethyl ether (5.0 mL), stirred for 30 min. and further diluted with water and extracted with DCM to furnish 280 mg of acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester.

Provenance & Evidence